The list below shows the largest American banks in terms of market capitalization as of November 17, 2017. JPMorgan Chase is the largest US financial institution with a market value of over $340 billion.
| Rank | Bank | Market cap (US$b, November 17, 2017) | Symbol |
| 1 | JPMorgan Chase | 340.520B | NYSE: JPM |
| 2 | Bank of America | 277.664B | NYSE: BAC |
| 3 | Wells Fargo | 266.650B | NYSE: WFC |
| 4 | Citigroup Inc | 188.600B | NYSE: C |
| 5 | Goldman Sachs Group | 93.596B | NYSE: GS |
| 6 | Morgan Stanley | 88.050B | NYSE: MS |
| 7 | U.S. Bancorp | 86.094B | NYSE: USB |
| 8 | American Express | 81.320B | NYSE:AXP |
| 9 | PNC Financial | 63.210B | NYSE: PNC |
| 10 | Charles Schwab | 59.897B | NYSE: SCHW |
| 11 | Bank of New York Mellon | 53.730B | NYSE: BK |
| 12 | Capital One | 42.575B | NYSE: COF |
| 13 | BB&T Corp | 36.937B | NYSE: BBT |
| 14 | State Street | 34.232B | NYSE: STT |
| 15 | SunTrust Banks | 27.500B | NYSE: STI |
| 16 | M&T Bank | 24.168B | NYSE: MTB |
| 17 | Discover Financial | 23.642B | NYSE: DFS |
| 18 | Northern Trust Corp | 21.394B | NASDAQ: NTRS |
| 19 | Fifth Third Bancorp | 20.074B | NASDAQ: FITB |
| 20 | KeyCorp | 19.691B | NYSE: KEY |
| 21 | Citizens Financial Group | 18.780B | NYSE: CFG |
| 22 | Regions Financial | 18.328B | NYSE: RF |
| 23 | First Republic Bank | 14.828B | NYSE: FRC |
| 24 | Huntington Bancshares | 14.636B | NASDAQ: HBAN |
| 25 | Comerica Inc | 13.762B | NYSE: CMA |
| 26 | E*TRADE Financial Corp | 11.914B | NASDAQ: ETFC |
| 27 | Ally Financial | 11.793B | NYSE: ALLY |
| 28 | SVB Financial Group | 11.351B | NASDAQ: SIVB |
| 29 | Zions Bancorporation | 9.248B | NASDAQ: ZION |
| 30 | East West Bancorp | 8.369B | NASDAQ: EWBC |
| 31 | Signature Bank | 7.095B | NASDAQ: SBNY |
| 32 | People's United Financial | 6.291B | NASDAQ: PBCT |
| 33 | CIT Group Inc | 6.270B | NYSE: CIT |
| 34 | New York Community Bancorp | 6.216B | NYSE: NYCB |
| 35 | Cullen/Frost Bankers | 6.025B | NYSE: CFR |
| 36 | PacWest Bancorp | 5.820B | NASDAQ: PACW |
| 37 | Commerce Bancshares | 5.698B | NASDAQ: CBSH |
| 38 | Synovus Financial | 5.544B | NYSE: SNV |
| 39 | BOK Financial Corp | 5.533B | NASDAQ: BOKF |
| 40 | Webster Financial Corp | 4.900B | NYSE: WBS |