The table below shows the largest U.S. commercial banks and bank holding companies ranked by market capitalization. JP Morgan Chase is the largest financial institution in the United States with a market capitalization of over $390 billion.
| Rank | Bank | Market cap (US$b, January 17, 2018) | Symbol |
| 1 | JPMorgan Chase | 392.044B | NYSE: JPM |
| 2 | Bank of America | 325.227B | NYSE: BAC |
| 3 | Wells Fargo | 314.562B | NYSE: WFC |
| 4 | Citigroup Inc | 204.831B | NYSE: C |
| 5 | Morgan Stanley | 100.067B | NYSE: MS |
| 6 | Goldman Sachs Group | 99.381B | NYSE: GS |
| 7 | U.S. Bancorp | 93.496B | NYSE: USB |
| 8 | American Express | 87.459B | NYSE:AXP |
| 9 | Charles Schwab | 75.193B | NYSE: SCHW |
| 10 | PNC Financial | 73.383B | NYSE: PNC |
| 11 | Bank of New York Mellon | 59.281B | NYSE: BK |
| 12 | Capital One | 50.602B | NYSE: COF |
| 13 | BB&T Corp | 42.034B | NYSE: BBT |
| 14 | State Street | 39.457B | NYSE: STT |
| 15 | SunTrust Banks | 32.537B | NYSE: STI |
| 16 | Discover Financial | 28.682B | NYSE: DFS |
| 17 | M&T Bank | 26.974B | NYSE: MTB |
| 18 | Northern Trust Corp | 24.309B | NASDAQ: NTRS |
| 19 | Fifth Third Bancorp | 22.924B | NASDAQ: FITB |
| 20 | KeyCorp | 22.863B | NYSE: KEY |
| 21 | Citizens Financial Group | 22.553B | NYSE: CFG |
| 22 | Regions Financial | 21.297B | NYSE: RF |
| 23 | Huntington Bancshares | 17.036B | NASDAQ: HBAN |
| 24 | Comerica Inc | 16.480B | NYSE: CMA |
| 25 | E*TRADE Financial Corp | 14.472B | NASDAQ: ETFC |
| 26 | First Republic Bank | 14.200B | NYSE: FRC |
| 27 | Ally Financial | 13.540B | NYSE: ALLY |
| 28 | SVB Financial Group | 13.429B | NASDAQ: SIVB |
| 29 | Zions Bancorporation | 10.650B | NASDAQ: ZION |
| 30 | East West Bancorp | 9.715B | NASDAQ: EWBC |
| 31 | Signature Bank | 8.085B | NASDAQ: SBNY |
| 32 | CIT Group Inc | 6.874B | NYSE: CIT |
| 33 | PacWest Bancorp | 6.754B | NASDAQ: PACW |
| 34 | People's United Financial | 6.735B | NASDAQ: PBCT |
| 35 | New York Community Bancorp | 6.695B | NYSE: NYCB |
| 36 | First horizon national | 6.623B | NYSE: FHN |
| 37 | Cullen/Frost Bankers | 6.396B | NYSE: CFR |
| 38 | BOK Financial Corp | 6.310B | NASDAQ: BOKF |
| 39 | Commerce Bancshares | 6.207B | NASDAQ: CBSH |
| 40 | Synovus Financial | 6.039B | NYSE: SNV |
| 41 | Webster Financial Corp | 5.455B | NYSE: WBS |